INNOSC Theranostics and Pharmacological Sciences <p align="justify"><em><strong>INNOSC Theranostics and Pharmacological Sciences</strong> (ITPS)</em> is a quarterly, Open Access and peer-reviewed journal, covering research across disciplines in all aspects of basic, experimental and clinical theranostics (therapeutic and diagnosis) and pharmacological sciences. This multidisciplinary open access journal is at the forefront of disseminating and communicating scientific knowledge and impactful research discoveries to researchers, academicians, clinicians, and the public worldwide.</p> <p align="justify">The journal publishes the high-quality peer-reviewed original research articles, reviews, mini-reviews, case reports, rapid communications, letters to the editor, preliminary data on innovative research and editorials in all aspects from the basic experiments to clinical phase trials on human diseases, ranging from molecular to higher animals. Furthermore, findings from theories to current cutting-edge technologies are welcomed.</p> <p>For more information about the journal, please visit the <strong><a href="">Focus and Scope</a></strong> of the journal.</p> en-US <p>Author(s) shall retain the copyright of their work and grant the Journal/Publisher rights for the first publication with the work concurrently licensed under <a href="">Creative Commons Attribution-Noncommercial 4.0 International License</a>. </p><p>Under this license, author(s) will allow third parties to download, reuse, reprint, modify, distribute and/or copy the content under the condition that the authors are given credit and that the work is not used for commercial purposes. No permission is required from the authors or the publisher.</p><p>This broad license intends to facilitate free access, as well as the unrestricted use of original works of all types. This ensures that the published work is freely and openly available in perpetuity. </p> (INNOCS Theranostics and Pharmacological Sciences) Wed, 05 Dec 2018 00:00:00 +0800 OJS 60 A Foreword from the Editor Subash C.B. Gopinath Copyright (c) 2018 Subash C.B. Gopinath Tue, 11 Dec 2018 00:00:00 +0800 Review on Chronic Exposure of Acrylamide Causes a Neurotoxicity Risk <p>The exposure and inhalation of acrylamide (ACR) are not safe to the human health leading to the potential neurotoxicity. ACR is widely used in biochemical techniques and highly occurs in processing foods such as potato chips prepared at high temperatures. ACR is formed from reducing sugars and asparagine through the Maillard reaction. It exerts various harmful and toxic effects such as neurotoxicity both in humans and animal studies. The extensive damage of synaptic proteins, the formation of ACR-DNA adducts, degeneration of motor neurons, neurofilament reduction, are the most common neurological symptoms. The main metabolite of ACR metabolism is glycidamide, and it causes harmful effects as same as ACR. The main purpose of this study is to analyze the neurotoxic effects of ACR on various regions of the brain and its different mechanistic pathways that are involved in ACR neurotoxicity. The consumption of ACR-containing foods and its exposure are reduced by the human, leading to the reduction of toxic effects associated with ACR.</p> Narendra Maddu, S. Fareeda Begum Copyright (c) 2018 Narendra Maddu Tue, 11 Dec 2018 00:00:00 +0800 Aptamer: A Versatile Probe in Medical Diagnosis Thangavel Lakshmipriya, Subash C.B. Gopinath Copyright (c) 2018 Thangavel Lakshmipriya Thu, 06 Dec 2018 00:00:00 +0800 Korean Red Ginseng: Benefits Versus Precautions <p>Over the years, Korean red ginseng (RG), scientifically known as Panax ginseng, has been used to treat several diseases. It is a prominent and ancient medicinal herb in the Orient. Ginseng ginsenoside is the major component of RG which has been presumed to be responsible for the health benefits of RG. Many studies on P. ginseng have until now concentrated on the mechanism of action of the individual components of RG. However, despite the numerous research on the molecular basis of P. ginseng activities, it is still confusing how several active components can simultaneously interact with several targets to give the diverse effects in different diseases. This overview covered the positive and negative effects of using the Korean RG; it also outlined the major chemical components of the Korean RG.</p> Essam A. Makky Copyright (c) 2018 Essam A. Makky Wed, 05 Dec 2018 15:36:25 +0800 Identification and Documentation of Potential Drug-Drug Interactions in Inpatients at a Tertiary Care Center Amaravadi Divya, Vasudha Bakshi, Boggula Narender Copyright (c) 2018 Boggula Narender Wed, 05 Dec 2018 15:36:25 +0800 Supplementation of Carrot Incorporated Paneer Attenuates Diabetes through its Antioxidant Potential in Streptozotocin-Nicotinamide-Induced Diabetic Rats <p><strong><em>Background:</em></strong> The ideal medications for diabetes mellitus (DM) should have less or no adverse effects, thus screening on the antidiabetic activities of plant-based products is in urgent need. Paneer is the fundamental nutritious and complete native dairy products, and natural products incorporated paneer has greatly increased its therapeutic potential.<br><em><strong>Objective:</strong></em> The current study was undertaken to explore the effects of carrot incorporated paneer (CIP) on blood glucose, body weight, insulin, and enzymatic antioxidants such as superoxide dismutase, catalase, glutathione (GSH) peroxidase, and reduced GSH in streptozotocin (STZ) and nicotinamide (NAD)-induced diabetes in rats.<br><em><strong>Materials and Methods:</strong> </em>Diabetic rats were orally supplemented with CIP (200 mg/kg body weight/day) for 1 month and the effects were compared with gliclazide (5 mg/kg body weight/day).<br><em><strong>Results:</strong></em> Supplementation of CIP or gliclazide was resulted in noteworthy diminish in the levels of blood glucose and increase in body weight and insulin levels. STZ-NAD administration caused the diminution in enzymatic antioxidant activities in diabetic rats and supplementation with CIP predominantly enhanced the levels of antioxidant enzymes in diabetic rats when contrasted to diabetic group.<br><em><strong>Conclusion:</strong> </em>Hence, the results suggested that CIP has the potential antioxidant capability and may be believed as an efficient curative constituent for the management of DM.</p> P.R. Nivedha, V.V. Sathibabu Uddandrao, Ganapathy Saravanan, Brahmanaidu P., S. Vadivukkarasi Copyright (c) 2018 P. R. Nivedha, V. V. Sathibabu Uddandrao1, Ganapathy Saravanan, P. Brahmanaidu, S. Vadivukkarasi Wed, 05 Dec 2018 15:36:25 +0800