INNOSC Theranostics and Pharmacological Sciences 2019-07-04T13:35:57+08:00 INNOCS Theranostics and Pharmacological Sciences Open Journal Systems <p align="justify"><em><strong>INNOSC Theranostics and Pharmacological Sciences</strong> (ITPS)</em> is a quarterly, Open Access and peer-reviewed journal, covering research across disciplines in all aspects of basic, experimental and clinical theranostics (therapeutic and diagnosis) and pharmacological sciences. This multidisciplinary open access journal is at the forefront of disseminating and communicating scientific knowledge and impactful research discoveries to researchers, academicians, clinicians, and the public worldwide.</p> <p align="justify">The journal publishes the high-quality peer-reviewed original research articles, reviews, mini-reviews, case reports, rapid communications, letters to the editor, preliminary data on innovative research and editorials in all aspects from the basic experiments to clinical phase trials on human diseases, ranging from molecular to higher animals. Furthermore, findings from theories to current cutting-edge technologies are welcomed.</p> <p>For more information about the journal, please visit the <strong><a href="">Focus and Scope</a></strong> of the journal.</p> A Foreword from the Editor 2019-07-04T13:21:15+08:00 Subash C.B. Gopinath 2018-12-11T00:00:00+08:00 Copyright (c) 2018 Subash C.B. Gopinath Review on Chronic Exposure of Acrylamide Causes a Neurotoxicity Risk 2019-07-04T13:24:56+08:00 Narendra Maddu S. Fareeda Begum <p>The exposure and inhalation of acrylamide (ACR) are not safe to the human health leading to the potential neurotoxicity. ACR is widely used in biochemical techniques and highly occurs in processing foods such as potato chips prepared at high temperatures. ACR is formed from reducing sugars and asparagine through the Maillard reaction. It exerts various harmful and toxic effects such as neurotoxicity both in humans and animal studies. The extensive damage of synaptic proteins, the formation of ACR-DNA adducts, degeneration of motor neurons, neurofilament reduction, are the most common neurological symptoms. The main metabolite of ACR metabolism is glycidamide, and it causes harmful effects as same as ACR. The main purpose of this study is to analyze the neurotoxic effects of ACR on various regions of the brain and its different mechanistic pathways that are involved in ACR neurotoxicity. The consumption of ACR-containing foods and its exposure are reduced by the human, leading to the reduction of toxic effects associated with ACR.</p> 2018-12-11T00:00:00+08:00 Copyright (c) 2018 Narendra Maddu Aptamer: A Versatile Probe in Medical Diagnosis 2019-07-04T13:26:43+08:00 Thangavel Lakshmipriya Subash C.B. Gopinath 2018-12-06T00:00:00+08:00 Copyright (c) 2018 Thangavel Lakshmipriya Korean Red Ginseng: Benefits Versus Precautions 2019-07-04T13:29:55+08:00 Essam A. Makky <p>Over the years, Korean red ginseng (RG), scientifically known as Panax ginseng, has been used to treat several diseases. It is a prominent and ancient medicinal herb in the Orient. Ginseng ginsenoside is the major component of RG which has been presumed to be responsible for the health benefits of RG. Many studies on P. ginseng have until now concentrated on the mechanism of action of the individual components of RG. However, despite the numerous research on the molecular basis of P. ginseng activities, it is still confusing how several active components can simultaneously interact with several targets to give the diverse effects in different diseases. This overview covered the positive and negative effects of using the Korean RG; it also outlined the major chemical components of the Korean RG.</p> 2018-12-05T15:36:25+08:00 Copyright (c) 2018 Essam A. Makky Identification and Documentation of Potential Drug-Drug Interactions in Inpatients at a Tertiary Care Center 2019-07-04T13:31:52+08:00 Amaravadi Divya Vasudha Bakshi Boggula Narender 2018-12-05T15:36:25+08:00 Copyright (c) 2018 Boggula Narender Supplementation of Carrot Incorporated Paneer Attenuates Diabetes through its Antioxidant Potential in Streptozotocin-Nicotinamide-Induced Diabetic Rats 2019-07-04T13:35:57+08:00 P.R. Nivedha V.V. Sathibabu Uddandrao Ganapathy Saravanan Brahmanaidu P. S. Vadivukkarasi <p><strong><em>Background:</em></strong> The ideal medications for diabetes mellitus (DM) should have less or no adverse effects, thus screening on the antidiabetic activities of plant-based products is in urgent need. Paneer is the fundamental nutritious and complete native dairy products, and natural products incorporated paneer has greatly increased its therapeutic potential.<br><em><strong>Objective:</strong></em> The current study was undertaken to explore the effects of carrot incorporated paneer (CIP) on blood glucose, body weight, insulin, and enzymatic antioxidants such as superoxide dismutase, catalase, glutathione (GSH) peroxidase, and reduced GSH in streptozotocin (STZ) and nicotinamide (NAD)-induced diabetes in rats.<br><em><strong>Materials and Methods:</strong> </em>Diabetic rats were orally supplemented with CIP (200 mg/kg body weight/day) for 1 month and the effects were compared with gliclazide (5 mg/kg body weight/day).<br><em><strong>Results:</strong></em> Supplementation of CIP or gliclazide was resulted in noteworthy diminish in the levels of blood glucose and increase in body weight and insulin levels. STZ-NAD administration caused the diminution in enzymatic antioxidant activities in diabetic rats and supplementation with CIP predominantly enhanced the levels of antioxidant enzymes in diabetic rats when contrasted to diabetic group.<br><em><strong>Conclusion:</strong> </em>Hence, the results suggested that CIP has the potential antioxidant capability and may be believed as an efficient curative constituent for the management of DM.</p> 2018-12-05T15:36:25+08:00 Copyright (c) 2018 P. R. Nivedha, V. V. Sathibabu Uddandrao1, Ganapathy Saravanan, P. Brahmanaidu, S. Vadivukkarasi